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Results for "

mPGES-1 inhibitor

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13283
    MF63
    1 Publications Verification

    		 PGE synthase Inflammation/Immunology
    MF63 is a selective and orally active inhibitor of mPGES-1. MF63 reduces the accumulation of PGE2, relieves pyresis, hyperalgesia, and inflammatory pain by inhibiting mPGES-1 .
    MF63
  • HY-126898
    5-LO/mPGES1-IN-1

    		Lipoxygenase PGE synthase Inflammation/Immunology
    5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC50 values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity .
    5-LO/mPGES1-IN-1
  • HY-100864
    mPGES1-IN-3

    		PGE synthase Inflammation/Immunology
    mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM) .
    mPGES1-IN-3
  • HY-N9814
    Shanciol B

    		NO Synthase Inflammation/Immunology
    Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .
    Shanciol B
  • HY-156612
    Friluglanstat

    		PGE synthase Inflammation/Immunology
    Friluglanstat is a prostaglandin E synthase (mPGES-1) inhibitor, with anti-inflammatory activity .
    Friluglanstat
  • HY-118282
    mPGES1-IN-7

    		PGE synthase Endocrinology
    mPGES-1-IN-2 (compound III) is a benzimidazole mPGES-1 inhibitor that reduces PGE2 production and tends to reduce levels of other prostaglandins.
    mPGES1-IN-7
  • HY-162166
    COX-2/15-LOX/mPGES1-IN-1

    		COX Lipoxygenase Inflammation/Immunology
    COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC50 values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments .
    COX-2/15-LOX/mPGES1-IN-1
  • HY-144237
    BRP-201

    		PGE synthase Inflammation/Immunology
    Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the research of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.
    BRP-201
  • HY-139589
    Zaloglanstat

    ISC-27864; GRC-27864

    		 PGE synthase Neurological Disease Inflammation/Immunology
    Zaloglanstat (ISC-27864) is the inhibitor of the microsomal prostaglandin E synthase-1 (mPGES-1), and can be used to study asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases, etc .
    Zaloglanstat
  • HY-118119
    CAY10526

    		PGE synthase Cancer
    CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1 .
    CAY10526
  • HY-147416
    Vipoglanstat

    BI 1029539; GS-248; OX-MPI

    		 PGE synthase Infection
    Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 (mPGES-1). Vipoglanstat also has anti-inflammatory activity .
    Vipoglanstat
  • HY-117008
    CAY10589

    		PGE synthase Inflammation/Immunology
    CAY10589 is an inhibitor of mPGES-1, an enzyme induced during inflammatory responses. CAY10589 has no significant effect on the differentiation of BM myeloid precursor cells into M2-like TAMs .
    CAY10589
  • HY-125415
    PF-4693627

    		PGE synthase Inflammation/Immunology
    PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA) .
    PF-4693627
  • HY-19622
    PF-9184

    		PGE synthase Inflammation/Immunology
    PF-9184 is a potent and highly selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), with an IC50 of 16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro .
    PF-9184
  • HY-162387
    UK4b

    		PGE synthase Cardiovascular Disease Inflammation/Immunology
    UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice .
    UK4b
  • HY-149202
    UT-11

    		PGE synthase Inflammation/Immunology
    UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50s of 0.10 μM and 2.00 μM for inhibiting PGE2 production in human (SK-N-AS) and murine (BV2) cells, respectively .
    UT-11
  • HY-B0084
    Dienogest
    1 Publications Verification

    STS 557

    		 Progesterone Receptor Endocrinology
    Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .
    Dienogest
  • HY-111140
    YS121

    		PGE synthase Lipoxygenase Inflammation/Immunology
    YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells .
    YS121
  • HY-125975
    1-Naphthyl 3,5-dinitrobenzoate

    		Lipoxygenase Inflammation/Immunology
    1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC50 values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC50 value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation .
    1-Naphthyl 3,5-dinitrobenzoate

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